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The new features on the purifier deliver additional sizes and sterilization/sanitization compatibility.
3M announced new features to its Emphaze AEX Hybrid Purifier on Sept. 5, 2018 that include sterilization/sanitization compatibility and additional sizes. The new Emphaze capsules are sterilization/sanitization compatible and can be used across various aqueous-based biopharmaceutical processes, including vaccine purification and now include two new laboratory-scale capsules and one scale-up capsule, allowing for evaluations at laboratory and scale-up volumes.
Emphaze AEX Hybrid Purifier products are synthetic multi-mechanism single-use purifier products used for biopharmaceutical clarification. They deliver consistent, high-purity clarified process fluid by removing soluble and insoluble impurities, such as DNA, host cell protein (HCP), and cell debris, through a combination of chromatographic and size-exclusion mechanisms. The product combines three 3M technologies-advanced polymer materials, fine fiber nonwovens, and membranes-to deliver a synthetic clarifying product line containing a new anion exchange nonwoven media and a fine particle, reduction membrane.
“Customer input is critical in evaluating the performance and effectiveness of any product to maximize performance,” said Himanshu Nivsarkar, global marketing manager, 3M Separation and Purification Sciences Division, in a company press release. “With the Emphaze AEX Hybrid Purifier, customers experience benefits in typical monoclonal antibody purification processes, including nominal 30% HCP and greater-than-4-log DNA reduction. It has a consistent output turbidity (<5 nephelometric turbidity unit) leading to potential downsizing of the sterilizing grade membrane and increased product purity post-protein A. This also reduces turbidity post viral inactivation/neutralization step leading to a lower impurities load on the downstream AEX column, thus allowing customers to optimize their processes.”