3M Enhances Emphaze AEX Hybrid Purifier

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The new features on the purifier deliver additional sizes and sterilization/sanitization compatibility.

3M announced new features to its Emphaze AEX Hybrid Purifier on Sept. 5, 2018 that include sterilization/sanitization compatibility and additional sizes. The new Emphaze capsules are sterilization/sanitization compatible and can be used across various aqueous-based biopharmaceutical processes, including vaccine purification and now include  two new laboratory-scale capsules and one scale-up capsule, allowing for evaluations at laboratory and scale-up volumes.

Emphaze AEX Hybrid Purifier products are synthetic multi-mechanism single-use purifier products used for biopharmaceutical clarification. They deliver consistent, high-purity clarified process fluid by removing soluble and insoluble impurities, such as DNA, host cell protein (HCP), and cell debris, through a combination of chromatographic and size-exclusion mechanisms. The product combines three 3M technologies-advanced polymer materials, fine fiber nonwovens, and membranes-to deliver a synthetic clarifying product line containing a new anion exchange nonwoven media and a fine particle, reduction membrane.

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“Customer input is critical in evaluating the performance and effectiveness of any product to maximize performance,” said Himanshu Nivsarkar, global marketing manager, 3M Separation and Purification Sciences Division, in a company press release. “With the Emphaze AEX Hybrid Purifier, customers experience benefits in typical monoclonal antibody purification processes, including nominal 30% HCP and greater-than-4-log DNA reduction. It has a consistent output turbidity (<5 nephelometric turbidity unit) leading to potential downsizing of the sterilizing grade membrane and increased product purity post-protein A. This also reduces turbidity post viral inactivation/neutralization step leading to a lower impurities load on the downstream AEX column, thus allowing customers to optimize their processes.”

Source: 3M