Wyatt Technology

Assessing a drug candidate early in discovery and development minimizes the risk of costly downstream failure. This white paper illustrates the application of automated DLS for aggregation and stability investigations.

This paper includes a brief introduction to light scattering instruments and techniques, and how they are coupled with fractionation techniques. For several classes of vaccines – including subunit vaccines, mRNA-LNPs, polysaccharide conjugates, and plain old viruses – case studies demonstrate the utility and breadth of analyses using the light scattering toolkit. These include measuring size distributions, characterizing protein-protein binding, and quantifying glycan content in glycoproteins or nucleic acid cargo in nanocarriers. Multiple ways to detect aggregation and other measures of stability are also described.

***Live: Tuesday, December 15, 2020 at 11am EST| 8am PST| 4pm GMT| 5pm CET*** Nanopharmaceuticals: the latest in standardized methods for characterization and quantification ***On demand available after final airing until Dec. 15, 2021***

*** Three Events: Tuesday, Oct. 27, 2020 at 11am EDT| 8am PDT| 3pm GMT| 4pm CET Asia Pacific: Wednesday, Oct. 28, 2020 at 10:30 am IST| 1pm CST| 2pm JST Europe: Wednesday, Oct. 28, 2020 at 9am| 10am CET*** Characterizing complex nanoparticles, polymers and biotherapeutics is about to get a lot easier. ***On demand available after final airing until Oct. 28, 2021***

Learn about real-time light scattering, a novel technology for measuring quality attributes of bio- and nano-pharmaceuticals directly in the process stream. Live: Wednesday, Feb. 26, 2020 at 11am EST | 8am PST | 4pm GMT | 5pm CET On demand available after airing until Feb. 26, 2021 Register free

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