Cynthia A. Challener

Stable producer cell lines show real promise despite continued development challenges.

Sourcing of donor cells, access to fit-for-purpose reagents and manufacturing systems, and scalability are top issues.

Despite many development challenges, stable producer cell lines show real promise.

When one is using continuous hot-melt extrusion to enhance solubility, process control is essential.

Media developers and vector manufacturers face a combination of challenges and opportunities.

Batch-to-batch variability and impurities present critical challenges.

Optimization strategies that leverage advanced technologies are essential for maximizing yield and quality.

Stability and in vivo performance aren't just affected by lipids.

The breakthrough approach is commonly used, but the devil is in the details.

Key challenges posed to autologous and allogeneic treatments could be resolved by in-vivo CAR-T gene therapies.