
Viragen Reports Protein Expression Breakthrough in Avian Transgenics
Viragen, Inc. (Plantation, FL, www.viragen.com), and its collaborative partners in the field of avian transgenics-Roslin Institute (Scotland, UK, www.roslin.ac.uk) and (Oxford, UK, www.oxfordbiomedica.co.uk)-have announced a significant breakthrough in the development of the OVA system, an avian transgenic protein expression technology.
Viragen, Inc. (Plantation, FL,
The OVA System uses lines of transgenic hens that have been engineered, using the LentiVector gene delivery system licensed from Oxford BioMedica, to produce a target protein in their eggs. In initial studies, the results of which were announced in January, expression levels of approximately 4 mg of interferon alpha per egg were achieved. Following further optimization using a modified proprietary regulatory sequence, the system’s output increased 10-fold. In the latest studies, each egg contained as much as 40 mg of interferon alpha, enough to treat up to 15 hepatitis C patients for a full year.
Viragen believes its technology can provide an efficient and economical alternative to traditional recombinant manufacturing techniques, particularly for difficult-to-manufacture proteins. “We have every reason to believe these results will translate to other high value therapeutic proteins,” said Dr. Karen Jervis, managing director of Viragen (Scotland) Ltd., in a published statement.
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