
Red Dye May be Effective Melanoma Treatment
A reformulated version of Rose Bengal, PV-10, may be used to treat melanoma when injected directly into tumors.
Rose Bengal was patented in the 1882 as a wool dye used to dye yarn a bright red color. Now, according to a report in Reuters, researchers are looking at the potential for the dye to help battle melanoma.
Provectus Biopharmaceuticals, a biopharma company focused on clinical stage dermatology and oncology, has been testing a reformulated version of the dye, called PV-10, on melanoma. According to Reuters, the founders of Provectus discovered that Rose Bengal could be used to fight cancer. In 1998, while searching for a photoreactive agent to use in a study of lasers and cancer, scientists discovered that the dye appeared to break down tumors when it was injected directly into them.
In July 2015, Provectus published an article in the
According to Reuters, in a study done with 80 advanced melanoma patients treated with PV-10, half appeared to be cancer free after an average of two months. A total of 11% showed no signs of the disease a year after completion of the study. Now researchers are waiting for the final results from a 225-patient melanoma trial, comparing the drug to chemotherapy. Results are expected until early 2018. A decision from FDA on the effectiveness of the drug is not expected before 2019, Reuters reported.
This is not the first time a dye has been discovered to have clinical implications. In a December 2015 study published in the journal Aging Cell, scientists at the University of Maryland discovered a connection between the
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