Pfizer and Medivation to Co-Develop and Market Alzheimer’s and Huntington’s Treatment

Pfizer Inc. (New York, NY) and Medivation, Inc. (San Francisco, CA) have joined forces to develop and commercialize Dimebon, Medivation’s investigational drug for treating Alzheimer’s disease and Huntington’s disease. Dimebon is currently being evaluated in an international, confirmatory Phase 3 trial in patients with mild-to-moderate Alzheimer’s disease (www.connectionstudy.com).

Under the terms of the agreement, Medivation will receive an up front cash payment of $225 million. Medivation and Pfizer will collaborate on the Phase 3 program in Alzheimer’s disease, Huntington’s disease, and regulatory filings in the United States. The companies will share all US development and commercialization expenses along with US profits/losses on a 60/40% basis, with Pfizer assuming the larger share of both expenses and profit/losses. In addition, Medivation will co-promote Dimebon to specialty physicians in the US.

Pfizer will have the responsibility for development, regulatory, and commercialization outside the US and will pay Medivation tiered royalties on commercial sales outside of the US.