The Swiss pharmaceutical company Novartis has opened a new vaccine manufacturing facility in Holly Springs, NC.
The Swiss pharmaceutical company Novartis has opened a new vaccine manufacturing facility in Holly Springs, NC. The plant, which is designed to supply 150 million doses of pandemic vaccine within six months of an influenza pandemic declaration, is the first large-scale flu cell culture vaccine and adjuvant manufacturing facility in the US.
The 430,000 sq. ft. facility is a result of a partnership between Novartis and the US Department of Health and Human Services (HHS). The total investment in the facility is nearly $1 billion, through a partnership between Novartis and HHS to support the design, construction, validation, and licensing of the plant.
If licensed in an emergency, the facility will be ready to respond to a pandemic as early as 2011. The plant is planned to be running at full-scale commercial production in 2013.
The facility also can start producing MF59, Novartis’s proprietary adjuvant, as early as December 2009. MF59 is licensed for use in Europe for Novartis’s cell culture-based Influenza A (H1N1) vaccine, Celtura.
Other companies, such as Baxter and Protein Sciences Corporation, are also developing influenza vaccines in cell culture for both pandemic and seasonal flu. The current outbreak of the H1N1 swine flu has accelerated interest in applying cell culture to influenza vaccine production.
The Future of Cleanroom Construction: How Hybrid Solutions are Changing the Game
May 14th 2025Imagine a world where cleanroom facilities—essential for pharmaceutical manufacturing, biotechnology, and high-tech industries—are built with unparalleled speed, precision, and efficiency. That world is here, thanks to the hybrid construction approach. By blending traditional stick-built methods with modular and prefabricated solutions, companies are overcoming the limitations of conventional construction while ensuring compliance with stringent industry regulations. In this interview, we explore how hybrid cleanroom construction is transforming the industry, offering faster project timelines, improved quality control, and significant cost advantages. Join us as we delve into this game-changing approach with industry experts who are leading the charge in revolutionizing cleanroom infrastructure.
Mastering Antibody-Drug Conjugates
December 19th 2024In this episode, we explore BIOVECTRA’s capabilities in antibody-drug conjugate (ADC) manufacturing, from complex conjugation chemistry to synthesis of highly potent payloads. We’ll also showcase how BIOVECTRA’s extensive experience in complex chemistries and specialized small molecule manufacturing gives them a unique perspective, strengthening their approach to ADC production and ensuring clients receive custom solutions across all project stages.
Kyron.bio Raises €5.5M to Advance Precision Glycan Engineering for Safer Antibody Therapeutics
May 28th 2025Funding will support the company’s efforts to refine its proprietary glycan-engineering platform, expand its scientific and operational team, and advance preclinical studies of its engineered biologics.