Merck KGaA has partnered with Telix Pharmaceuticals to conduct combination clinical studies for cancer therapy.
On Aug. 18, 2021, Telix Pharmaceuticals, an Australian-based radiopharmaceutical company, announced a collaboration with Merck KGaA, Darmstadt, Germany, to conduct clinical combination studies for cancer treatment. The studies will combine one of Merck’s investigational proprietary DNA damage response inhibitor (DDRi) molecules with each of Telix’s molecularly targeted radiation (MTR) therapeutic programs—TLX591 (177Lu-rosopatamab) and TLX250 (177Lu-girentuximab). This collaboration builds on a strategic research collaboration agreement the two companies began in August 2019.
TLX591 and TLX250 are late-stage products in development for prostate and renal cancer therapy, respectively. Under the collaboration and based on encouraging pre-clinical data from their initial research partnership, the two companies have agreed to investigate the synergy of these product assets with Merck’s DDRi compound across a wide variety of oncology indications in the clinic.
“This collaboration represents the vanguard of nuclear medicine and oncology, and we are excited by the level of new data and intellectual property already generated, which is highly supportive of clinical translation. Pre-clinical studies provide evidence that the combined effect of Merck’s DDRi compound with Telix’s MTR candidates has potential to significantly impact cancer by improving efficacy and reducing the required radiation dose for tumor reduction and remission, compared to MTR only,” said Christian Behrenbruch, CEO, Telix, in a company press release.
Source: Telix Pharmaceuticals
Psilera, Hesperos Agree to Accelerate Organ-on-a-Chip Treatment for Frontotemporal Dementia
June 9th 2025The partnership leverages the Hesperos organ-on-a-chip platform in the preclinical development of Psilera’s lead compound targeting the progressive neurological disorder for which treatment options are few.