Sangamo  BioSciences, Inc. (Richmond,   CA) has entered into a second  research and license agreement with Genentech, Inc. (South San Francisco, CA), expanding on the original  agreement to include additional targets for potential improvement of production  cell lines using Sangamo's proprietary zinc finger DNA-binding protein nuclease  (ZFN) technology.

Zinc finger  proteins (ZFPs) are the dominant class of naturally occurring transcription  factors in organisms from yeast to humans. Transcription factors, which are  found in the nucleus of every cell, bind to DNA to regulate gene expression.  Though there are many kinds of transcription factors, only ZFPs are amenable to  engineering and precise targeting to a particular gene or genes of interest.  ZFNs are engineered forms of ZFPs that also contain a nuclease component, which  can induce modification of a target gene of interest.

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Sangamo BioSciences, Inc. (Richmond, CA) has entered into a second research and license agreement with Genentech, Inc. (South San Francisco, CA), expanding on the original agreement to include additional targets for potential improvement of production cell lines using Sangamo's proprietary zinc finger DNA-binding protein nuclease (ZFN) technology