Leo de Leede



Leo de Leede is a director of preclinical research and development at OctoPlus NV.


Advances in Single-Shot Vaccine Development

The disadvantages of the traditional vaccine regime (prime plus boost) have spurred the development of single-shot vaccines. This article describes the development and manufacture of a prototype single-shot vaccine that uses microspheres made from cross-linked modified dextran polymers for controlled release of the antigen.