Dualitas Therapeutics has entered a research collaboration and license agreement with Roche to discover and develop novel bispecific antibodies (BsAbs) for immunology and inflammation (I&I) diseases using Dualitas's DualScreen bispecific discovery engine, Dualitas announced September 17, 2026.¹ The company will receive a $36.5 million upfront payment and is eligible for additional research, development, and commercial milestone payments plus tiered royalties. The deal is valued at potentially up to $1 billion.¹
Key facts
- Companies: Dualitas Therapeutics; Roche
- Technology: DualScreen bispecific discovery engine (proximity biology)
- Scope: Functional screening of 300,000+ BsAb combinations
- Disease area: Immunology and inflammation
- Deal terms: $36.5 million upfront; up to $1 billion total with milestones and royalties
- Deal structure: Dualitas discovers; Roche leads all subsequent development/commercialization
- Company milestone: DTX-102 expected to enter clinic in 2027
- Geography: US-based (South San Francisco); global collaboration
"We are thrilled to partner with Roche on this first-of-its-kind collaboration to functionally screen and develop novel proximity BsAbs at a scale that was previously unachievable," said Forbes Huang, co-founder, chief operating officer, and chief business officer of Dualitas, in a company press release.¹ The company’s DualScreen discovery engine has established a next-generation BsAb pipeline that will be entering the clinic next year for I&I diseases, according to Huang.
What will the collaboration screen for, and how does DualScreen work?
Under the agreement, Dualitas will use its DualScreen platform to functionally screen more than 300,000 novel bispecific antibody combinations, which the companies describe as one of the largest-scale bispecific discovery efforts to date.¹ Unlike traditional bispecific approaches that focus on pre-determined target pairs for incremental gains, DualScreen functionally screens entire cell surfaces across a vast range of targets and epitopes to identify candidates with synergistic activities that are unattainable with conventional therapeutics, accordig to Dualitas.¹ The discovery engine leverages the company's expertise in proximity biology. Roche will be responsible for all subsequent preclinical development, regulatory, manufacturing, and commercial activities for candidates arising from the collaboration.
What did Roche say about the deal?
"Bispecific antibodies remain central to Roche's portfolio strategy across many disease areas," said Boris L. Zaïtra, head of corporate business development at Roche, in the release.¹ "We are committed to continue pushing the boundaries of scientific innovation in immunology and inflammation diseases that will ultimately benefit patients through external partnerships."
