Chromatography Columns

April 1, 2020

BioPharm International

Volume 33, Issue 4

Page Number: 56

Shim-pack Bio Diol and IEX columns from Shimadzu Scientific Instruments improve the accuracy of the characterization of peptides, oligonucleotides, and other biopharmaceuticals.

Shim-pack Bio Diol and IEX columns from Shimadzu Scientific Instruments improve the accuracy of the characterization of peptides, oligonucleotides, and other biopharmaceuticals. The columns are available in quaternary ammonium and sulfopropyl chemistries and are positioned on porous and non-porous hydrophilic polymers with low nonspecific adsorption.

The columns come equipped with different pore sizes for an accurate analysis of aggregates and fragments of monoclonal antibodies, oligonucleotides, and carbohydrates. Particle sizes from 5 μm to 2 μm can be reduced, which improves the resolution between aggregates and monomers. The column lengths can also be reduced from 300 mm to 150 mm using a 2 μm particle, which leads to a 50% shorter run time while keeping up with resolution.

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