Downstream Processing

Purification of Antibodies Using Novel Convecdiff Membranes Part 2

In part 2 of this article, results from the testing of a next generation convecdiff membrane are discussed.

Purification of Antibodies Using Novel Convecdiff Membranes Part 1

The testing of new convecdiff membranes shows this material to be well suited for lab- and commercial-scale bind-and-elute applications.

Choosing the Right Resins for Viral Vector Affinity Chromatography

Affinity chromatography resins must perform well under mild elution conditions yet withstand robust cleaning and sanitization protocols.

Considerations for Simplifying Downstream Processes

October 01, 2022

A simplified downstream process can save time and costs but requires enabling technologies.

Approaches to Scaling Up Chromatography Processes

September 01, 2022

Scaling up chromatography resins requires a thorough understanding of their intended use.

Developing Automation Downstream

August 02, 2022

Automation enables intensification of downstream processes.

Quality by Design for Affinity Chromatography

July 01, 2022

Enriching process understanding enables robust process controls.

Merck Collaborates with Agilent Technologies on PAT for Downstream Processing

June 17, 2022

Merck has entered into a collaboration with Agilent Technologies with the aim of filling the industry gap in PAT for downstream processing.

Advancing Process Chromatography in DSP

June 01, 2022

Thanks to technological advances, process chromatography challenges are surmountable, but increasingly complex therapies in the pipeline will demand more efficient processes in the future.

Driving Efficiencies in DSP Separation and Purification

May 03, 2022

An increasingly complex development pipeline and industry considerations, such as sustainability, are leading to a greater need for more efficient separation and purification in downstream processing.

Automating Cell Harvesting for Cell Therapies

May 01, 2022

Some progress has been made, but improvements are needed when harvesting cells for cell therapies.

Intensifying Downstream Processes

April 02, 2022

The need to increase efficiency and productivity is driving adoption.

What’s New in Downstream Processing?

April 01, 2022

The past year of downstream processing has brought innovations in pH sensitive antibody purification, single-use fermentation separators, and more.