Downstream Processing

Rentschler Biopharma to Launch US Center of Excellence

November 07, 2019

The new addition will also launch a single-use bioreactor for the 93,000-ft2 facility.

What’s New in Manufacturing: Downstream Technologies

November 01, 2019

The latest advances in downstream technologies include stainless-steel liquid chromatography columns, sensing and control units for hygienic valves, a wettable phase for separation and purification, a buffer delivery platform, and a new filter integrity tester.

Using TEM-Based Image Analysis to Validate the Presence of HA Spikes on Influenza VLPs

November 01, 2019

The authors of this study demonstrate an innovative method that is useful and complements traditional HA assays.

Packing Capto ImpRes Resins with Verified Packing Methods

October 11, 2019

Poorly packed columns can lead to loss of valuable product. Use these verified packing methods for Capto ImpRes resins when packing large-scale chromatography columns.

Novel Hydrophobic Interaction Chromatography Resins for Next Generation Biotherapeutic Challenges

September 20, 2019

Designed to solve complex downstream separation and purification challenges for many biotherapeutic modalities, a suite of hydrophobic chromatography resins (POROS HIC) has been developed that cover a wide range of hydrophobicity.

BIA Separations Launches AAV Process Development Service to Accelerate Gene Therapy Production

September 19, 2019

The new program, Cornerstone, integrates process development expertise and novel technology to remove development bottlenecks in the manufacture of gene therapy medicinal products.

Plan Now to Share Your Expertise in 2020

September 01, 2019

The editors welcome technical article contributions from biopharma industry experts.

Monitoring and Control of Inline Dilution Processes

August 01, 2019

Successful process intensification with inline dilution requires effective monitoring and control.

Enhancing Cell Harvest

August 01, 2019

Higher cell densities are driving innovations in harvesting, including closed systems for intensified processes.

Analysis of Residual Impurities in Continuous Manufacturing

July 01, 2019

Real-time monitoring of product- and process-related impurities remains a challenge.