Robust Oligonucleotide Molecular Weight Confirmation by LC-MS

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Webinar Date/Time: Airing 1: Tuesday, June 25th, 2024 at 8am PDT | 11am EDT | 4pm BST | 5pm CEST Airing 2: Tuesday, June 25th, 2024 at 11am PDT | 2pm EDT | 7pm BST | 8pm CEST Airing 3: Wednesday, June 26th, 2024 at 11am JST | 7pm PDT | 9pm CST

This webcast will cover molecular weight confirmation of oligonucleotides by LC/MS, focusing on the use of fit-for-purpose deconvolution software.

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Event Overview:

Molecular weight confirmation is a critical analytical workflow for the development of therapeutic oligonucleotides. This webinar demonstrates oligo molecular confirmation and simple characterization by LC/MS. The combination of user-friendly software, robust hardware, and unique column chemistry enables routine molecular weight confirmation for oligos of varying lengths and modifications.

Key Learning Objectives:

  • Understand molecular weight confirmation for oligonucleotides by LC/MS using fir-for-purpose deconvolution software.
  • Learn how to optimize your IP-RP LC/MS analytical methods to improve resolution of your target product from closely related impurities.
  • Discover how the Agilent LC/MS SQ portfolio will help you develop, characterize, purify, and verify your oligonucleotides.

Who Should Attend:

  • Oligonucleotide Analytical Method Development Scientists
  • Oligonucleotide Purification Method Development Scientists
  • Oligonucleotide Process Development Scientists
  • Oligonucleotide QC Scientists
  • Oligonucleotide CDMO Labs
  • Oligonucleotide Developability and Development Scientists


Brian Rivera
Product Manager
Agilent Technologies

Brian Rivera is Software Product Manager at Agilent Technologies and has 20 years of experience in HPLC analysis of large molecules. His previous industry experience includes positions at Chiron Corporation (now Novartis), ProZyme, and Avid Bioservices. Additionally, he was Product Manager at Phenomenex, focusing on HPLC column development for monoclonal antibodies and oligonucleotides. He has a bachelor’s degree from the University of California, Davis.

Connor Flannery
Product Manager
Agilent Technologies

Connor Flannery is Global Product Manager for HPLC Biocolumns at Agilent Technologies. Prior to his work in product management, he worked as an R&D product development chemist. His work focused on the development and characterization of novel stationary phases for targeted LC applications, as well as high pressure column-packing technologies.

Russell Burge
Product Manager
Agilent Technologies

Russell Burge earned a Ph.D. in Biochemistry and Molecular Biology from Scripps Research (La Jolla, CA). He has extensive experience as a scientist in the R&D of biomolecules and biopharmaceuticals, and as an application scientist for laboratory automation systems and advanced sensor systems. Russell has managed several life sciences and industrial products, most recently of which are the LC/MS SQ and LC/MS TOF portfolios at Agilent.

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