Orjana Terova is global product manager for POROS chromatography products, Bioproduction at Thermo Fisher Scientific (Bedford MA, USA).
Hydrophobic interaction chromatography (HIC) in flow-through mode offers a more efficient and cost-effective polishing/purification process to remove monoclonal antibody aggregates while maintaining purity at ≥99% than a mixed-mode bind/elute procedure.
A case study demonstrates that affinity chromatography can offer efficiency and scalability for gene therapy manufacturing using viral vectors.
September 28th 2018
