Charge Detection Mass Spectrometry: From Complexity to Clarity—Simplify Sizing of Viral Vectors and Proteins

Obtain a deeper understanding of how CDMS complements and supersedes alternative techniques and enhances resolution in quality assessments across biotherapeutic development stages and in research of structural biology.

Register Free: https://www.biopharminternational.com/bp_w/charge-detection

Event Overview:

Charge detection mass spectrometry (CDMS) is reshaping the landscape of characterization of complex biotherapeutics by transforming the analysis of large, heterogeneous biomolecular complexes and gene therapy vectors.

Join the webinar and see firsthand how electrostatic linear ion trap (ELIT)–based charge detection mass spectrometry (CDMS) enables direct mass and charge measurements of individual ions, delivers unprecedented insights into complex large biomolecules, from recombinant adeno-associated virus (rAAV) characterization to proteasomal complex stoichiometry.

Attendees will obtain a deeper understanding of how CDMS complements and supersedes alternative techniques and enhances resolution in quality assessments across biotherapeutic development stages and in research of structural biology.

Key Learning Objectives:

• Gain insights into the ELIT-based CDMS technology and its working mechanisms
• Learn how CDMS enhances rAAV vector characterization while comparing with AUC (Area Under the Curve) and MP (Minimum Plasma concentration)
• See how CDMS provides deeper insights into the study of proteasomal complexes

Who Should Attend:

Primary audience:

• structural biologists
• analytical scientists
• gene therapy researchers
• biopharmaceutical development professionals

Secondary audience:

• mass spectrometry specialists
• quality control analysts
• regulatory scientists

Featured Speakers:

Ben Draper, PhD
Co-founder and Research Scientist
Megadalton Solutions

Ben Draper, PhD, a cofounder of Megadalton Solutions, has designed and built charge detection mass spectrometry (CDMS) instruments at Megadalton. During his 7-year tenure at Megadalton, Draper has been instrumental in the continuing improvement of CDMS technology, especially in driving and exploring application of CDMS in areas such as gene therapy, vaccines, nucleic acids, synthetic nanoparticles.

Draper received a PhD in physical chemistry in 2018 from Indiana University Bloomington, mentored by Martin F. Jarrold, PhD. CDMS instrumentation development was the focus of Draper’s thesis, most notably, streamlining CDMS data acquisition and analysis to achieve a speedup of 100 times, which allowed data analysis to occur in real-time.

Speaker's Email: bdraper@megadaltonsolutions.com
Speaker's LinkedIn: Benjamin Draper

Stacy Nash, PhD
Scientist II
Ultragenyx

Stacey Nash, PhD, is a scientist II in an analytical development (AD) department in Ultragenyx. Focused on developing gene therapy–based treatment for rare diseases, Ultragenyx leverages AAV as a delivery vehicle. During her 2-year tenure at Ultragenyx as part of the AD team supporting process development, Nash has been instrumental in supporting biologics license application enabling characterization of gene therapies. She adapts biophysical approaches and applies her background in mass spectrometry to compare orthogonal techniques to measure empty/full capsid ratio of AAV capsids.

Nash received her PhD in biological mass spectrometry from the University of Massachusetts Amherst under the mentorship of Richard Vachet, PhD, during which she developed mass spectrometry–based approaches to characterize structural changes in protein complexes, including during amyloid formation.

Speaker's Email: SNash@ultragenyx.com
Speaker's LinkedIn: Stacey Nash

Siavash Vahidi, PhD
Associate Professor
University of Guelph

Siavash Vahidi, PhD, is an assistant professor in the Department of Molecular and Cellular Biology at the University of Guelph in Canada. In his lab, established in 2020, Vahidi’s research program takes an integrative approach to structural biology, combining mass spectrometry, NMR, crystallography, and cryo-EM to investigate large proteolytic systems such as the proteasome.

Vahidi received his PhD in biophysical mass spectrometry from Western University under the mentorship of Lars Konermann, PhD, followed by postdoctoral fellowship in biomolecular NMR with Lewis Kay, PhD, at the University of Toronto. During his tenure at the University of Toronto, Siavash also worked closely with John Rubinstein, PhD, on cryo-EM.

The Vahidi lab is supported by grants and awards from the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada.

Speaker's Email: svahidi@uguelph.ca


Register Free: https://www.biopharminternational.com/bp_w/charge-detection