Downstream Processing

Cynthia A. Challener, PhD, is a contributing editor to BioPharm International.

Articles

New therapeutics modalities and the need for greater process efficiency are driving technology development.

Chromatographic Science Clarifies Separation Challenges

The latest advances in downstream technologies include a fluid chromatography system, sensing and control units for hygienic valves, a compact valve platform, a membrane purification column, and a protein A affinity chromatography resin.

What’s New in Downstream Technologies

The latest advances in downstream technologies include stainless-steel liquid chromatography columns, sensing and control units for hygienic valves, a wettable phase for separation and purification, a buffer delivery platform, and a new filter integrity tester. 

What’s New in Manufacturing: Downstream Technologies

The latest advances in process chromatography include pre-packed chromatography columns, process characterization kits, fast protein liquid chromatography systems, and mixed-mode chromatography resins. 

What’s New in Manufacturing: Process Chromatography

Pharmaceutical Technology and BioPharm International will present a Keynote Session on Meeting Bioprocessing Manufacturing Capacity Demands on Wednesday, April 3, 2019, during INTERPHEX 2019 at the Javits Center in New York City.

Biologic Drug Manufacturing Capacity on the Agenda for INTERPHEX 2019 Keynote Series

Downstream process equipment for mAbs manufacturing must be designed to fit technology developments in upstream processes.

Membrane Technology for Enhancing Separation and Purification

New ligands are being developed to meet the separation and purification needs of next-gen biologics.

A Look at the Affinity Chromatography Landscape

The investment builds on a collaboration the companies entered into in 2007 for various biomanufacturing projects.

Tosoh Bioscience Moves to Acquire Semba Biosciences

GE’s new facility, which will be operational in 2019, will produce a fiber-based chromatography platform for more efficient biopharmaceutical purification. 

GE Healthcare Opens Biotechnology Manufacturing Center in UK

The new features on the purifier deliver additional sizes and sterilization/sanitization compatibility.

3M Enhances Emphaze AEX Hybrid Purifier

Bio-Rad introduces CHT Ceramic Hydroxyapatite XT media and Nuvia HP-Q resin resin for process protein purification.

Chromatography Resin Designed to Boost Process-Scale Productivity

New products were developed as next-generation process intensification technologies, MilliporeSigma reports.

MilliporeSigma Adds CEX Resin and Amino Acids

Automation can improve many aspects of bioprocessing, but several hurdles must be overcome before the full range of benefits can be realized.

Evaluating the Rewards vs. the Risks of Automation

The media, by Tosoh Bioscience, is composed of calcium and phosphate buffers and offers mixed-mode properties for biomolecule purification.

Hydroxyapatite Chromotography Media Offers Enhanced Biomolecule Purification

The new resin used a combination of “jetting” technology and a high-performance Protein A ligand.

Purolite Launches New Protein A Resin

More published data and initial regulatory approvals are needed to drive adoption of continuous bio-manufacturing. 

Managing Uncertainty in Continuous Biomanufacturing

Process understanding and careful assessment of risks are essential in developing viral clearance programs. 

Putting Viral Clearance Capabilities to the Test

Early adopters are benefiting from lower costs and increased productivity.

Making the Move to Continuous Chromatography

The Wilden Quattroflow QF10k size pump from PSG, a Dover company, has been designed to fill the gap between the existing QF4400/5050 and QF20k pump sizes.

Additional Size for Quaternary Diaphragm Pumps

Advances in TFF and single-use systems help advance UF/DF on the continuous processing path. 

Manufacturing, Process Chromatography