Downstream Processing

Articles

The launch of HiScreen Fibro PrismA, the company’s newest product for early mAb purification process development strengthens Cytiva’s new fiber-based Protein A platform.

Cytiva Advances Fiber Chromatography Technology with New Launch

The transaction will include operations located at different Novasep sites, including its Pompey, France site and sites in the United States, China, and India. 

Sartorius Acquires Novasep’s Chromatography Equipment Division 

Thomas Prouzeau is a purification process development scientist at Sanofi.

Jerome Pezzini, Jerome.pezzini@sanofi.com, is purification process and technology leader at Sanofi.

Benoit Mothes is purification process development group head at Sanofi.

The development of an innovative purification process simplifies downstream processing for biologics.



EASY: a Disruptive mAb Purification Process to Reduce Cost of Goods

Feliza Mirasol is the science editor for 

Establishing an automated inline dilution system can potentially ease bottlenecking delays resulting from higher upstream yields.

Using Automated Inline Dilution to Ease Bottlenecking

Kilian Brand is lab technician downstream process development at 

Florian Capito is lab head downstream process development 

Verena Oeinck is lab technician downstream process development at 

Hendrik Flato is lab engineer downstream process development at Sanofi-Aventis Deutschland GmbH.

Marc Bisschops is director at Pall Medistad.

Martin Glenz is principal scientist at Pall GmbH.

Ralf Ehret is vice dean at Provadis School of International Management and Technology.

Continuous SEC was shown to increase productivity with the same product quality and yield.

Continuous Preparative SEC for Purification of “Difficult-to-Manufacture” Proteins–A Feasibility Study

The latest advances in downstream technologies include sterile disconnects for single-use manufacturing systems, ligand technologies for purifying RNA and for COVID-19 vaccines, and an automated perfusion system.

What’s New in Downstream Technologies 

Cynthia A. Challener, PhD, is a contributing editor to BioPharm International.

New therapeutics modalities and the need for greater process efficiency are driving technology development.

Chromatographic Science Clarifies Separation Challenges

The latest advances in downstream technologies include a fluid chromatography system, sensing and control units for hygienic valves, a compact valve platform, a membrane purification column, and a protein A affinity chromatography resin.

What’s New in Downstream Technologies

The latest advances in downstream technologies include stainless-steel liquid chromatography columns, sensing and control units for hygienic valves, a wettable phase for separation and purification, a buffer delivery platform, and a new filter integrity tester. 

What’s New in Manufacturing: Downstream Technologies

The latest advances in process chromatography include pre-packed chromatography columns, process characterization kits, fast protein liquid chromatography systems, and mixed-mode chromatography resins. 

What’s New in Manufacturing: Process Chromatography

Pharmaceutical Technology and BioPharm International will present a Keynote Session on Meeting Bioprocessing Manufacturing Capacity Demands on Wednesday, April 3, 2019, during INTERPHEX 2019 at the Javits Center in New York City.

Biologic Drug Manufacturing Capacity on the Agenda for INTERPHEX 2019 Keynote Series

Downstream process equipment for mAbs manufacturing must be designed to fit technology developments in upstream processes.

Membrane Technology for Enhancing Separation and Purification

New ligands are being developed to meet the separation and purification needs of next-gen biologics.

A Look at the Affinity Chromatography Landscape

The investment builds on a collaboration the companies entered into in 2007 for various biomanufacturing projects.

Tosoh Bioscience Moves to Acquire Semba Biosciences

GE’s new facility, which will be operational in 2019, will produce a fiber-based chromatography platform for more efficient biopharmaceutical purification. 

GE Healthcare Opens Biotechnology Manufacturing Center in UK

The new features on the purifier deliver additional sizes and sterilization/sanitization compatibility.

3M Enhances Emphaze AEX Hybrid Purifier

Bio-Rad introduces CHT Ceramic Hydroxyapatite XT media and Nuvia HP-Q resin resin for process protein purification.

Chromatography Resin Designed to Boost Process-Scale Productivity

New products were developed as next-generation process intensification technologies, MilliporeSigma reports.

MilliporeSigma Adds CEX Resin and Amino Acids

Automation can improve many aspects of bioprocessing, but several hurdles must be overcome before the full range of benefits can be realized.

Evaluating the Rewards vs. the Risks of Automation

The media, by Tosoh Bioscience, is composed of calcium and phosphate buffers and offers mixed-mode properties for biomolecule purification.

Manufacturing, Process Chromatography