mAb characterization using flash oxidation technology and mass spectrometry

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Webinar Date/Time: Thu, Mar 28, 2024 11:00 AM EDT

Enhance your understanding of higher order structure for protein therapeutics with protein footprinting technology coupled to high-resolution mass spec with EAD.

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Event Overview:

The higher order structure (HOS) of protein therapeutics is integral to a drug's stability, safety and biological function. Incorrect configurations of HOS or interactions with therapeutic targets can lead to adverse drug reactions. In-cell fast photo-oxidation of proteins (IC-FPOP) enables the exploration of the effects of epitope/paratope mapping, aggregation-interface identification, formulation, small molecule binding and other factors, thereby enhancing the understanding and significance of therapeutic HOS.

Key Learning Objectives:

  • Learn what the Fox® Protein Footprinting System is
  • Learn how to characterize biotherapeutic HOS using the Fox® Protein Footprinting System
  • Learn the benefits of high-resolution mass spectrometry for HOS characterization on the ZenoTOF 7600 system

Who Should Attend:

  • Chief Scientific Officers
  • VPs of Drug Discovery
  • VPs of Proteomics
  • Lab Directors
  • Principal Scientists


Zhi (Selina) Cheng, PhD
Applied Research Scientist
GenNext Technologies Inc.

Dr. Zhi Cheng is an Applied Research Scientist at GenNext Technologies, Inc. In this role, Dr Cheng focuses on the use of LC-MS techniques for proteomics studies, including in-cell fast photo-oxidation of proteins (IC-FPOP) for proteome-wide structural biology to characterize cellular drug–target interactions. She received her PhD in Analytical Biochemistry from the University of Mississippi under the direction of Professor Joshua Sharp. During her studies with Professor Sharp, Dr Cheng served as the primary scientist responsible for the development of on-line HRPF labeling of samples separated by liquid chromatography using both excimer lasers and GenNext's Flash Oxidation (Fox®) system. Dr Cheng is an expert in HRPF, proteomics and glycomics.

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