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May 20, 2021
Read a case study about resin screening, process development, and scale-up purification of a retrovirus-like particle which was scalable, fast, and low-cost during the clinical-grade manufacture of retrovirus vectors.
March 23, 2021
Used by leading pharma companies and CDMOs, the Beacon system offers an integrated end-to-end automated workflow for mammalian cell line development. Clones can be selectively enriched for unique phenotypes and multiple assays can be used to rapidly measure productivity of different antibody molecules.
November 23, 2020
The proportional–integral–derivative (PID) control mechanism is used for a variety of processes, including dissolved oxygen (DO) control. This protocol introduces a method developed to optimize the PI values on Eppendorf bioprocess controllers.
November 20, 2020
Traditional sequential chromatography usually requires user manipulation which may hinder reproducibility in protein purification runs. Multidimensional chromatography improves the process without sacrificing efficacy. This study compares both purification workflows demonstrating equivalent purity.
November 19, 2020
October 27, 2020
It can be challenging to define suitable operational definitions for volume-dependent parameters for upstream bioprocesses. In this work, we perform robust DoE mass-transfer characterization of the BIOne SUB and utilize a kʟa criterion to successfully define such parameters for a HEK-293 process.
July 21, 2020
COVID-19 has greatly influenced the global vaccine developmental landscape. •New bioprocess technologies create possibilities for quality control and validation.
January 07, 2020
• Using stirred-tank bioreactors for stem cell culture provides advantages. • Factors to consider include OTR, agitation speed, and impeller blades. • An eight-blade impeller can address challenges associated with scale-up.
December 18, 2019
The Synergy Tube is a BCT specifically designed to optimize nucleic acid recovery and cancer tumor cells (CTC) from the point of blood draw. The Synergy Tube and proprietary stabilizer dramatically improve the quantity and quality of these components for downstream genetic diagnostics.