It can be challenging to define suitable operational definitions for volume-dependent parameters for upstream bioprocesses. In this work, we perform robust DoE mass-transfer characterization of the BIOne SUB and utilize a kʟa criterion to successfully define such parameters for a HEK-293 process.
Stay at the forefront of biopharmaceutical innovation—subscribe to BioPharm International for expert insights on drug development, manufacturing, compliance, and more.