Use an HRAM LC-MS approach to cell culture media metabolite profiling to develop a targeted quantitative assay that monitors and quantifies multiple classes of cell culture media metabolites simultaneously in a single LC-MS run. Demonstrate that the developed quantitative assay can be used to support upstream processing optimization and quality control with excellent quantitative performance, high throughput and robustness.
A new approach using the novel, easy-to-connect Thermo Scientific MAbPac RP capillary column for determining glycosylation site occupancy of therapeutic antibodies from the analysis of their tryptic digest.
***Session 1: Thursday, April 22, 2021, 10am EDT, Session 2: Thursday, April 22, 2021, 11am EDT, Session 3: Thursday, April 22, 2021, 1pm EDT*** A drug’s journey from development to manufacturing to patients is paved with roadblocks and potholes; many threats can derail bio/pharmaceutical processes. Potential solutions to such pitfalls have been discussed for years; however, few manufacturers have embraced technology and process advances to proactively ensure drug supply chain continuity.
***Available Now!*** In this webinar, Mike Knierman, Eli Lilly, will discuss the use of mass spectrometry to identify unique sequences from SARS-CoV-2 spike glycoprotein extracellular domain in a complex with human leukocyte antigen class II molecules on antigen presenting cells from healthy donors. This work exemplifies the value-add of mass spectrometry in vaccine development. *On Demand until March 30, 2022*
Learn about the use of the MAbPac RP capillary column for utmost sensitivity and excellent selectivity for the mass spectrometric analyses of intact proteins and mAb subunits.
Three major workflows for characterizing biopharmaceuticals on a LC-MS platform: intact mass analysis under native and denaturing conditions, subunit analysis complemented with Middle-Down analysis, and peptide mapping.
***Live: Tuesday, Feb. 23, 2021 at 11am EST | 8am PST | 4pm GMT | 5pm CET*** In this webinar, Mike Knierman, Eli Lilly, will discuss the use of mass spectrometry to identify unique sequences from SARS-CoV-2 spike glycoprotein extracellular domain in a complex with human leukocyte antigen class II molecules on antigen presenting cells from healthy donors. This work exemplifies the value-add of mass spectrometry in vaccine development. *On Demand until Feb. 23, 2022*
This study demonstrates the use of the workflow for sequence variant assessment and to monitor the variability of product quality attributes in biosimilar when compared to its originator.
Get more out of your sample prep. Prevent sample failures in bioanalytical workflows and search application notes by your compounds of interest, application area, SOLA chemistry phases or SOLA formats.
This application note collection will help ensure you have the right tools to succeed in the biopharmaceutical environment, from research and process development to quality control.
***Live: Wednesday, Oct. 14, 2020, at 11am EDT| 8am PDT| 4pm BST| 5pm CEST*** Hear experts review key milestones and tasks—as well as potential stumbling blocks—along the drug development pathway and offer strategies to help discovery-phase drug development programs move from the lab to clinic and commercialization. *** On demand available after final airing until Oct. 14, 2021.***
This application note collection will help ensure you have the right tools to succeed in the biopharmaceutical environment, from research and process development to quality control.
