|Articles|May 15, 2002

BioPharm International

  • BioPharm International-05-01-2002
  • Volume 15
  • Issue 5

Freezing Bulk-Scale Biopharmaceuticals Using Common Techniques ? and the Magnitude of Freeze-Concentration

by Serena Donnelly Webb, David F. Sesin, Aimee C. Kincaid, Jonathan N. Webb, and Timothy G. Hughes, Integrated Biosystems, Inc. Large-scale freezing and thawing is commonly used in biopharmaceutical manufacturing but is not well understood. Freeze-thaw variations can exist within or between batches, and nonuniform processes raise serious validation concerns.
To view a PDF of this article from the BioPharm International archives, click this link

Articles in this issue

over 23 years ago

Info+

over 23 years ago

Analytical Advances: Strategies in Clarifying Mammalian Cultures

over 23 years ago

Analytical Advances: Using Image Informatics - Focusing Proteomics

over 23 years ago

The Not-So-Sure Thing

over 23 years ago

Washington Report: Vaccine Shortages put Spotlight on Production

over 23 years ago

Outsourcing Outlook: E-Procurement ? Successfully Using and Managing Reverse Auctions

over 23 years ago

Guest Editorial: Validation Bingo

over 23 years ago

Travel Notes: Yes, Virginia, There is Biotech in the Commonwealth

over 23 years ago

Development of an In Situ Spectroscopic Method for Cleaning Validation using Mid-IR Fiber-Optics

over 23 years ago

Validation of Large-Scale Chromatographic Processes, Part 1: Case Study of Neuleze Capture on Macroprep High-S

Newsletter

Stay at the forefront of biopharmaceutical innovation—subscribe to BioPharm International for expert insights on drug development, manufacturing, compliance, and more.

Subscribe Now!