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Articles

Methodology Development for Complete Nucleoside and Nucleotide Monitoring within Cell Samples

Tuesday, February 8th, 2022 at 9am EST | 3pm CET | 2pm GMT and 2pm EST | 11am PST | 7pm GMT Approaches and lessons learned on developing an HPLC methodology to cover a complex and broad range of polar analytes: the complete cellular pool of nucleosides and nucleotides plus our drug candidates and associated prodrugs. The utility of PEEK-lined columns and newer HILIC-Z column phases is highlighted in this anecdote of HPLC methodology development.

Determination of Multiple Attributes of mAbs

This application note describes multi-attribute analysis of monoclonal antibodies. The analyzer combines multidimensional chromatographic multimethod analysis options.

Refining Charge Variant Analysis of mAbs with the Agilent 1290 Infinity II Bio LC System

The 1290 Infinity II Bio LC including High-Speed Pump, with its iron‑free flow path, is optimally suited for the conditions used in biochromatography.

Support for Title 21 CFR Part 11 and Annex 11 Compliance

This paper describes the requirements for electronic records and electronic signatures for regulated pharmaceutical organizations.

High Salt—High Reproducibility

Analysis of antibody drug conjugates using hydrophobic interaction chromatography with the Agilent 1290 Infinity II Bio LC System

mAb Titer Determination in 60 Seconds Using the Agilent Bio‑Monolith rProtein A Column

The Agilent Bio-Monolith rProtein A (recombinant protein A) analytical column is the latest addition to the Bio-Monolith and affinity chromatography family.

Elevate Your mAb Aggregate Analysis

Superior resolution in size exclusion chromatography (SEC) protein separation made possible by the Agilent 1290 Infinity II Bio LC System.

Robust and Reliable Peptide Mapping

The Agilent 1290 Infinity II Bio LC System is the new platform for UV and MS-based primary structure and PTMs analysis of mAbs.

A Comprehensive Approach for Monoclonal Antibody N-linked Glycan Analysis

This study demonstrates how to increase sample throughput for glycan characterization workflows using the Agilent AssayMAP Bravo liquid handling platform.

Seamless Method Transfer to the Agilent 1290 Infinity II Bio LC System

Peptide-mapping analysis shows excellent performance and high method compatibility compared to the Agilent 1290 Infinity II LC System.