Increase Downstream Productivity and Decrease Costs with Multi-column Continuous Chromatography

Multi-column continuous chromatography (MCC) offers significant economic advantages over traditional batch methods for the purification of monoclonal antibodies (mAbs), including increased resin capacity utilization, smaller columns, reduced buffer consumption, and faster processing time. For mAb productivity, the Protein A capture step is a primary target to apply MCC due to its high cost, which is driven even higher as improvements in upstream processing have produced a steady increase in mAb titers. The multi-column continuous chromatography method has demonstrated that mAb productivity can be increased by 400 to 500% compared to batch-mode.