|Articles|March 15, 2002
- BioPharm International-03-15-2002
- Volume 15
- Issue 3
The Importance of Freezing on Lyophilization Cycle Development
Author(s)Thomas W. Patapoff, David E. Overcashier
by Thomas W. Patapoff and David E. Overcashier Genentech, Inc. The freezing method used during lyophilization can substantially affect the structure of the ice formed, the water-vapor flow during primary drying, and the quality of the final product. Controlling how a solution freezes can shorten lyophilization cycles and produce more stable formations.
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