Bioreactor Enhances Process Control

Published on: 
BioPharm International, BioPharm International-01-01-2015, Volume 28, Issue 1



Sartorius Stedim Biotech’s BIOSTAT Cplus is a fermenter/bioreactor designed for the cultivation of microorganisms and cell cultures. The bioreactor is ideal for process development of vaccines, recombinant protein and monoclonal antibody production, biofuels, and secondary metabolites. Process strategy development can also be applied in batch, fed-batch, and continuous or perfusion operation, as well as scale-up and scale-down experiments. Culture vessels are available in operating volumes of 5, 10, 15, 20, and 30 liters.

A built-in sterilizable-in-place system is equipped with a DCU controller for upstream and downstream processes. The system allows up to four mass flow controllers and up to two scales or gravimetric feed controllers, and includes a pressure hold test to ensure control and safety. Each individual system can be adjusted for application-specific requirements, with automatic pressure control or integrated off-gas measurement options available.

Sartorius Stedim