Virus Inactivation in the 1990s and into the 21st Century

April 15, 2003

Gail Sofer, Jeri Ann Boose, Dorothy C. Lister

BioPharm International, BioPharm International-04-01-2003, Volume 16, Issue 4

by Gail Sofer, BioReliance Dorothy C. Lister, and Jeri Ann Boose Smallest of the microorganisms, viruses depend on other cells ? like those used by biopharmaceutical manufacturers ? for reproduction. And viruses and drug products are idiosyncratic: Both the inactivation process and the product strongly influence the successful outcome. In this conclusion to the virus inactivation series, model ivruses are used to represent single- and double-stranded DNA and RNA viruses, to enable you to reach conclusions about effective inactivation methods for a range of viruses.