Systematic Troubleshooting for LC/MS/MS: Part 1, Sample Preparation and Chromatography

Published on: 
BioPharm International, BioPharm International-11-01-2001, Volume 14, Issue 11

by Naidong Weng and Timothy D.J. Halls Covance Laboratories, Inc. LC/MS/MS provides superior sensitivity and selectivity, rapid analysis, maximized development efficiencies, and improved turnaround times. Although large-scale LC/MS/MS analysis is fraught with challenges, you can learn to overcome the obstacles with careful planning and these troubleshooting techniques. Part 1 presents troubleshooting techniques related to sample preparation and chromatography.