Solutions and Solvents Improve Analytical Instrument Performance

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Flush solutions for liquid chromatography mass spectrometry (LC-MS) systems and ultrapure solvents for ultra-high-performance LC-MS systems from Thermo Fisher Scientific can minimize interference and maximize lab instrument uptime.

Thermo Fisher Scientific has added a range of flush solutions for liquid chromatography mass spectrometry (LC-MS) systems and a new line of ultrapure solvents for ultra-high-performance LC-MS (UHPLC-MS) systems.

According to the company, laboratories can minimize interference and maximize instrument uptime with the ChromaCare flush solutions and UHPLC-MS ultrapure solvents-acetonitrile, methanol, water, and isopropyl alcohol. The reagents can reduce contaminants and prevent protein precipitation, and the UHPLC-MS solvents are suited for pharmaceutical, biotech, clinical and academic laboratory applications. 

The product range was developed for both start-up and upkeep of delicate LC-MS columns and chromatographs and includes two new reagents designed to ensure continuous operation of the company’s LC-MS systems. The LC-MS Instrument Flush Solution reduces background noise, facilitating instrument installation and preventative maintenance routines. The LC-MS Biologics Flush Solution prevents proteins from clogging probes, minimizes instrument downtime, and preserves sample integrity.

The ultrapure solvents can help push the detection limits of UHPLC-MS systems to achieve high-quality separation results by enhancing mass sensitivity and resolution, reducing formation of metal ion adducts, and improving peak profiles, the company reports. The solvents enable optimal signal-to-noise ratio while keeping UV-absorbing and MS-ionizing impurities to a minimum, providing baselines with extremely low levels of background interference, regardless of the detector used. 


Because they are ultra-filtered, the solvents are can reduce downtime due to clogging of the instrument, columns, and check valves, helping to meet the continuous workflow demands of laboratories. The solvents are packaged in borosilicate bottles to reduce leaching of metal cations and to avoid sample contamination.

Source: Thermo Fisher Scientific