Artelis and Selexis Announce 31 g/L Yields in Multiple Perfusion Harvests

September 9, 2008
BioPharm International Editors

Artelis SA (Brussels, Belgium) and Selexis SA (Geneva, Switzerland) have announced  manufacturing yields of more than 31 grams per liter in a CHO-based monoclonal antibody production process, in multiple harvests from a perfusion-like process.

Artelis and Selexis Announce 31 g/L Yields in Multiple Perfusion Harvests
Artelis SA (Brussels, Belgium) and Selexis SA (Geneva, Switzerland) have announced  manufacturing yields of more than 31 grams per liter in a CHO-based monoclonal antibody production process, in multiple harvests from a perfusion-like process.

The high yields were achieved by applying a high-performance Selexis CHO production cell line and the iCELLis platform, a scalable, disposable, high-cell-density technology developed by scientists at Artelis.

The full program was concluded over about four months, starting with a high-performance cell line development at Selexis, followed by cell transfer and manufacturing at Artelis. The culture media used throughout the study was industry-standard cGMP grade and void of serum or any animal-derived components. Artelis and Selexis plan to expand the testing of the combined technologies by evaluating the iCELLis platform with Selexis-generated HEK293 cells lines.

iCELLis is a proprietary, single-use, technology developed by Artelis, designed to achieve and maintain high-cell densities on macrocarriers in a fixed-bed system. According to the company, these high-cell densities allow the compact iCELLis bioreactors to equal the productivity of much larger stirred-tank units.

Selexis release

Related Content:

News