The Feasibility of Tangential Flow Filtration for Cell Lysate Clarification

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Is it realistic to believe that tangential flow filtration (TFF), commonly used for concentration, desalting, buffer exchange, and protein fractionation, is now a viable alternative to centrifugation for cell harvest and cell lysate clarification? A new generation of membranes expands the possibilities for TFF as an economical, efficient, high-yielding process substitute, according to this case study’s author.