Bristol-Myers Squibb Makes Changes in R&D Locations and Focus

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Bristol-Myers Squibb builds R&D facilities in Massachusetts and San Francisco and discontinues discovery research in virology.

Bristol-Myers Squibb plans to open a new research site in Cambridge, Massachusetts in addition to the ongoing expansion of the company’s R&D Discovery site in the San Francisco Bay Area, the company announced on June 25, 2015. The new facility in Cambridge is expected to open in 2018. The ongoing site expansion in the San Francisco Bay Area adds 61000 ft2 of laboratory and office space at the Woodside Technology Park life-science campus and is expected to be completed in 2016. Consistent with evolution of the R&D organization’s strategic focus, which was previously announced in 2013, the company also announced its plans to discontinue discovery research efforts in virology. This decision does not impact the company’s promising ongoing clinical development program in virology, nor does it impact the company’s marketed products in virology, according to the press release.

“In addition to investments in central New Jersey, our new location in Cambridge and our expanding presence in the San Francisco Bay Area positions the company and our scientists in the heart of vibrant ecosystems of world class science, innovation, and business opportunities, which offer ideal environments for fostering external collaboration,” said Francis Cuss, executive vice-president and chief scientific officer at Bristol-Myers Squibb, in the press release. “Ultimately, our goal is to continue to accelerate the translation of scientific knowledge and insights into the next wave of potentially transformational medicines for patients with serious diseases.”

R&D sites
In Cambridge, Bristol-Myers Squibb scientists will focus on the company’s ongoing discovery efforts in genetically defined diseases, molecular discovery technologies, and discovery platform chemistry. In addition to relocating up to 200 employees from its Wallingford, Connecticut and Waltham, Massachusetts sites, and a limited number from its central New Jersey locations, the company expects to recruit scientists from the Cambridge area. As part of this transition, the Waltham site is expected to close in early 2018. The existing site in Wallingford will also close in early 2018 with up to 500 employees relocating to a new location in Connecticut. Bristol-Myers Squibb and Alexandria Real Estate Equities have a signed letter of intent for the Cambridge location and expect to sign a lease in the near future.

The Woodside Technology Park life-science campus in the San Francisco Bay Area serves as Bristol-Myers Squibb’s Discovery hub for researching breakthrough cancer immunotherapies. With additional square footage leased, Bristol-Myers Squibb will fully occupy two of the three buildings at the campus totaling 194,100 ft2 and will provide additional capacity to conduct biologics drug discovery research. In addition to relocating approximately 40 Bristol-Myers Squibb scientists from its Seattle, Washington site, the company will also recruit scientists from the Bay Area.


R&D focus
Consistent with the evolution of the company’s R&D strategic focus, which was announced in 2013, the Discovery organization will discontinue its research efforts in virology. This includes early research in hepatitis B (HBV) and HIV. Approximately 100 Discovery positions will be eliminated as a result of these changes.

The decision to discontinue Discovery research in virology does not impact the company’s ongoing development programs in virology, which includes the HIV attachment inhibitor BMS-663068, the HIV maturation inhibitor BMS-955176, beclabuvir, and the anti-PD-L1 compound BMS-936559, or the company’s marketed virology medicines, including Baraclude (entecavir), Reyataz (atazanavir)/Evotaz (atazanavir and cobicistat), Sustiva (efavirenz), Atripla (efavirenz/emtricitabine/tenofovir disoproxil fumarate), Daklinza (daclatasvir), and Sunvepra (asunaprevir). Bristol-Myers Squibb also remains committed to the registration and commercialization of Daklinza around the world, the company said in the press release. Bristol-Myers Squibb’s Discovery organization will continue to focus on research in immuno-oncology as well as heart failure, fibrosis, genetically defined diseases, and immunoscience.

Bristol-Myers Squibb