New Pilot-Scale Lyophilizer Aids Biologics Drug Development

Article

SP Scientific Products’ SP Hull LyoStar 4.0 R&D freeze dryer supports rapid freeze-dry cycle development, optimization, and process scale-up.

SP Scientific Products (SP) launched its SP Hull LyoStar 4.0 R&D and process development freeze dryer is based on a full-scale production freeze dryer to support rapid lyophilization cycle development, optimization, and scale-up. The pilot-scale lyophilizer offers shelf mapping and rapid shelf freezing, as well as a suite of process analytical technology (PAT) tools. In addition, the equipment uses a more eco-friendly refrigerant gas that reduces the carbon footprint involved in lyophilization.

PAT tools used by the equipment include LyoFlux TDLAS sensors for vapor mass flow measurement; AutoM/SMART Freeze Dryer Technology, a primary drying cycle optimization tool; ControLyo Nucleation Technology, which gives pinpoint control of freezing point; a three-dimensional modeling package for computational fluid dynamics and process monitoring; and Tempris wireless sensors for real-time product temperature measurement.

The equipment was designed to both scale up to production and down to R&D as part of SP’s Line of Sight approach across all its products. The LyoStar 4.0 scales up to the SP Hull LyoConstellation line of production lyophilizers and uses the same efficient refrigeration technology. Line of Sight also enables continuous process monitoring and improvement, in line with Pharma 4.0.

Source: SP Scientific Products

Newsletter

Stay at the forefront of biopharmaceutical innovation—subscribe to BioPharm International for expert insights on drug development, manufacturing, compliance, and more.

Recent Videos
Shortcut from point A to point B | Image Credit: © Olivier Le Moal - stock.adobe.com
Behind the Headlines, Episode 21: Waters-BD Merger, Merck’s $10B Bet, and Biotech’s Investment Frontiers
Wooden blocks spelling TARIFFS are placed on a map of North America, specifically over the United States and Mexico | Image Credit: © Rokas - stock.adobe.com
Jason Waite, International Trade Expert, Alston & Bird
DC skyline at night with view of the White House and the Washington Monument | Image Credit: © Jessica - stock.adobe.com
Related Content
© 2025 MJH Life Sciences

All rights reserved.