BioPharm International-06-02-2008

BioPharm International

The Role of Media Development in Process Optimization: An Historical Perspective

June 02, 2008

Articles

2008 Supplement

5

With a variety of recombinant, animal-free, defined protein supplements such as growth factors, transferrin, and albumin entering the market, the biopharmaceutical industry now has innovative and safer alternatives to serum and other animal-derived supplements.

Fusion Tags for Protein Expression and Purification

June 02, 2008

Articles

2008 Supplement

5

Gene fusion tags can improve the yield and solubility of many recombinant proteins. This article discusses the most popular fusion tags and the proteases used to remove them, with special reference to recently introduced technologies.

Improving Protein Production in CHO Cells

June 02, 2008

Articles

2008 Supplement

5

Using chemically defined feeds with CHO cell lines not only eliminates the variability associated with using plant hydrolysates, but could also improve the productivity of biopharmaceutical protein manufacture and help move therapeutic proteins into clinical trials more rapidly.

Maximizing Yields of Plasmid DNA Processes

June 02, 2008

Articles

2008 Supplement

5

Recombinant protein and plasmid DNA production using microbial expression systems is the cornerstone of many biologics manufacturing processes. HCD methods are commonly used for these processes because of the advantages they provide.