BioPharm International-05-02-2007

Growth of CHO cell cultures in a shaker plate model system was demonstrated to be comparable to growth in shake flasks.

Energy input is affected by rocking the chamber back and forth, generating a fluid movement in the cell culture and medium.

In addition to existing guidance, in January 2007 the FDA announced further proposals to prohibit the use of certain bovine materials as ingredients in some medical products or as elements of product manufacturing.

Protein expression remains an arduous task that involves a complex decision tree. Establishing tools and optimal conditions for each protein remains an empirical exercise.