Upstream Processing

Oct 01, 2008
BioPharm International
The year 2007 witnessed the approval of fifteen biopharmaceuticals in the United States and European Union.
Sep 01, 2008
BioPharm International
How to implement a risk-based approach to eliminating viruses.
Sep 01, 2008
BioPharm International
By BioPharm International Editors
There are several challenges associated with protecting patents for personalized medicines.
Aug 01, 2008
BioPharm International
A review of some recent contributions in process chromatography.
Jun 02, 2008
BioPharm International
Recombinant protein and plasmid DNA production using microbial expression systems is the cornerstone of many biologics manufacturing processes. HCD methods are commonly used for these processes because of the advantages they provide.
Jun 02, 2008
BioPharm International
Using chemically defined feeds with CHO cell lines not only eliminates the variability associated with using plant hydrolysates, but could also improve the productivity of biopharmaceutical protein manufacture and help move therapeutic proteins into clinical trials more rapidly.
Jun 02, 2008
BioPharm International
Gene fusion tags can improve the yield and solubility of many recombinant proteins. This article discusses the most popular fusion tags and the proteases used to remove them, with special reference to recently introduced technologies.
Jun 02, 2008
BioPharm International
With a variety of recombinant, animal-free, defined protein supplements such as growth factors, transferrin, and albumin entering the market, the biopharmaceutical industry now has innovative and safer alternatives to serum and other animal-derived supplements.
Jun 02, 2008
BioPharm International
A discussion of past achievements and future expectations of recombinant protein production yields from mammalian cells.
Jun 01, 2008
BioPharm International
Process-modeling tools can ensure smooth tech transfer.
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