Increasing efficiency and throughput in downstream separation and purification performance is currently a major focus in the biopharmaceutical industry. Traditional TFF systems cannot be scaled in a linear fashion to meet the projected demand for fermentation and cell culture based products. NCSRT has created a patented line of filtration solutions that address the bottlenecks currently experienced as biopharmaceutical products scale up from clinical trials to blockbuster production quantities.
SmartFlow TFF: NCSRT's novel SmartFlow technology incorporates a patented ribbed design that forces uniform flow across the entire membrane surface unlike traditional TFF cassettes. The incorporation of these unique ribs is the result of applying this practical design approach to TFF fuid dynamics. The improved fluid dynamics extends the performance well beyond what is possible with traditional TFF.
The performance advantage provided by OPTISEP SmartFlow TFF also applies to protein concentration applications.
OPTISEP filter modules accommodate ultra, micro, and nano filtration, and reverse osmosis membranes, enabling optimal processing solutions in the laboratory, pilot plant, and manufacturing suite. The modules are available in the variety of pore size, polymer, and supports. The OPTISEP product family provides direct linear scale up without loss of efficiency from 1 ft.2 (0.09 m2 ) to full systems operating over 8560 ft.2 (800 m2 ).
1. Davies ET, Tellez M, and Unger M. Isolation of proteins from fermentation broth of high cell density with a new cross flow filtration. Aachen Membrane Colloquium Proceedings. Aachen, Germany; 2005 Apr.
2. Chubet R, Kacmar J, and Kopf H. Development of a novel platform FF system for insect cell culture harvest. Advances in Separations and Purification Supplement to Biopharm Int. 2006; Jun 3.