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Defining PQAs Linked to Color Change in Biotherapeutics During Process Development
This event is available on demand!
Event Overview:
Because a product quality attribute (PQA) may impact efficacy and safety, the color of a protein therapeutic under process development, and any changes to that color require close monitoring. Establishing multi-attribute methodology (MAM) to track the cause of color change facilitates efficiency in this monitoring by enabling rapid hot spot analysis for the continued development of the drug. This webinar discusses the use of a LC-MS workflow for detailed peptide mapping of PTMs to:
Define potential PQAs associated with color change
Investigate the link between color change and advanced glycan end products (AGEs)
Characterize and localize AGEs linked to color change
Establish a MAM to quantitatively track AGEs
Key Learning Objectives:
Learn how to establish potential CQAs through in-depth characterization.
Discover the benefits of electron activated dissociation mass spectrometry for characterizing labile PTMs.
Develop and implement novel workflows to respond to new challenges.
Who Should Attend:
Biopharma Scientists, QC scientists, Process Control scientist, Analytical development labs, Cell Line development scientists, Early development
Featured Speaker
Andrew D. Mahan, PhD
Associate Director – Mass Spec Group Leader, Cell Engineering and Analytical Sciences
Janssen Research
Dr Andrew D. Mahan
is enthusiastic and passionate about mass spectrometry and its role in bringing new medicines to patients. His mission focuses on the continuous improvement of mass spectrometry and in the flawless execution of analytical methods to support the organizations and teams he is a part of. Dr Andrew D. Mahan received his PhD in analytical chemistry from Drexel University and is currently the Associate Director and Mass Spec Group Leader of Cell Engineering and Analytical Sciences at
Janssen Research in Spring House, PA, USA. There, he is focused on the analytical support of the cell line development group, applying mass spectrometry to solve problems and understand protein
expression
.
Speaker’s LinkedIn:
https://www.linkedin.com/in/andrew-mahan/
For any technical questions, please contact
Nicole Valle:
nvalle@mjhevents.com
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