Whitepapers

Oct 13, 2017
Sponsored Content
By SCIEX
Peptide-based mass spectrometry methods are generally preferred for the site-specific quantitation of oxidation levels of biotherapeutics. In this study, differential levels of oxidation were induced by incubating a monoclonal antibody standard with increasing concentrations of oxidizing agent (H2O2) prior to digestion. The high-quality data obtained from the X500B instrument, in combination with BioPharmaView™ software, allowed accurate and automated quantitation of sites susceptible to oxidation, making it a robust tool for routine sequence coverage analysis, as well as quantitation of critical quality attributes.
Sep 25, 2017
Sponsored Content
Uncle is an all-in-one stability platform that enables 11 different applications. In this application note, we describe NISTmAb data collected on the Uncle platform that demonstrates the versatility, reliability and ease-of-use of the instrument.
Sep 19, 2017
Sponsored Content
TOYOPEARL NH2-750F resin is a salt tolerant AEX resin ideal for the removal of endotoxins in mAb. It works in the presence of 150 mmol/L NaCl and a relatively low pH.
Sep 15, 2017
Sponsored Content
By SCIEX
The SCIEX X500B QTOF System with BioPharmaView™ Software enables routine characterization of biologics through all stages of discovery and development. The following study demonstrates these capabilities for the characterization of different manufactured lots of the biotherapeutic Trastuzumab. With streamlined workflows, SCIEX solutions simplify intact protein analysis, sub-unit analysis, peptide mapping, identification of modifications, and comparability analyses.
Sep 15, 2017
Sponsored Content
By Croda
Super Refining effectively removes or reduces polar and oxidative impurities, namely: moisture; residual catalyst; peroxide and aldehydes. The process does not alter the chemical structure of the excipient in any way. The removal of these impurities provides a range of added value to the formulator including enhanced API stability, improved oxidative stability, reduced cellular irritation, enhanced skin permeation and reduced taste impact.
Sep 14, 2017
Sponsored Content
In the pharmaceutical industry, speed to market is essential for gaining a competitive position. New encapsulation technologies now make it possible to streamline research and development activities, improve product development, and jump-start time to market.
Aug 18, 2017
Sponsored Content
TOYOPEARL® AF-rProtein L-650F resin, with a binding capacity of >70 g\L IgG, is used to capture and purify Fabs and scFv fragments. The resin is stable at 0.1 M NaOH.
Aug 04, 2017
Sponsored Content
The Agilent 1290 Infinity II 2D-LC solution with an Agilent 6530 Accurate Mass Quadrupole Time-of-Flight LC/MS was used to determine critical differences between an infliximab originator and candidate biosimilar.
Jul 21, 2017
Sponsored Content
This application note discusses the best critical cleaning practices for the pharmaceutical industry.
Jul 20, 2017
Sponsored Content
This whitepaper presents a study, undertaken by TruTag Technologies and their technical collaborator, Colorcon, and demonstrates that the application of TruTag® microtags has no impact on the drug release, assay, or appearance of pharmaceutical tablets after exposure to accelerated storage conditions.
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