Whitepapers

May 24, 2016
BioPharm International
A complete view of stability studies on biologics. The end goal is to help drug developers save unnecessary costs and delays in their timelines, and facilitate getting safer medicines to patients.
May 24, 2016
BioPharm International
The objective of this application note is to demonstrate that the ACQUITY QDa Detector provides a simple and cost-effective solution for detecting oligonucleotides across a wide molecular weight range and can be readily integrated into existing UV-based workflows.
May 17, 2016
BioPharm International
TOYOPEARL NH2-750F is a very effective anion exchange resin for the removal of endotoxin in a flow-through chromatography mode. This Application Note demonstrates that TOYOPEARL NH2-750F will reduce endotoxin in a sample to levels below the limit of detection for an LAL assay, in this instance greater than 6.7 logs.
May 13, 2016
BioPharm International
Discover how you can reduce energy consumption and environmental impact with production-level centrifuges, such as the new Thermo Scientific Sorvall BIOS 16 bioprocessing centrifuge.
Apr 22, 2016
BioPharm International
Agilent provides a complete ADC DAR determination solution that includes automated affinity purification with the Agilent AssayMAP Bravo, LC/MS acquisition with the Agilent 1290 Infinity UHPLC and Agilent 6550 Q-TOF, deconvolution with Agilent MassHunter BioConfirm software, and DAR determination with the Agilent BioConfirm DAR Calculator.
Apr 22, 2016
BioPharm International
Reversed-phase LC/MS is the routine method for the analysis of mAbs at intact or fragment level, which provides accurate molecular mass. The LC column and method is critical for successful separations.
Apr 21, 2016
BioPharm International
Maurice’s CE-SDS application analyses IgG purity and heterogeneity in a fast and robust format. The streamlined workflow simplifies batch set-up and Compass for iCE automatically analyzes the data for you.
Apr 19, 2016
BioPharm International
This Application Note demonstrates the analysis of charge variants of Rituximab (both innovator and biosimilar molecules) using multiple heart-cutting 2D-LC with MS detection.
Apr 13, 2016
BioPharm International
CaPure-HA hydroxyapatite resin is ideal for the intermediate (post-protein A) purification of mAbs where aggregates and other impurities are removed from the target of interest through multiple modes of product-resin interactions. While traditionally used in a bind-and-elute mode, CaPure-HA can also be used as a flow-through process step for aggregate removal.
Mar 30, 2016
BioPharm International
By BioPharm International Editors
The reversed phase analysis of an ADC using an Agilent 1290 Infinity LC system coupled to an Agilent 6550 iFunnel Q-TOF with Agilent LC columns can be extensively used to reproducibly generate accurate DAR values on both intact and reduced ADCs with excellent performance.
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