Upstream Processing

Mar 01, 2016
BioPharm International
Miniature bioreactors add value by reducing validation efforts.
Mar 01, 2016
BioPharm International
Microbial models offer some exciting production alternatives.
Mar 01, 2016
BioPharm International
Collaborative efforts are underway between suppliers and drug manufacturers to address raw material variability.
Mar 01, 2016
BioPharm International
The necessity to detach cells from a culture substrate during cell harvesting remains one of the most challenging steps in a cell-culture process.
Mar 01, 2016
BioPharm International
The authors describe the ways in which manufacturers can mitigate the risks related to the integrity of recombinant transgenes expressed in CHO cells.
Feb 01, 2016
BioPharm International
The use of orthogonal methods to SEC is discussed; examples show how analytical ultracentrifugation, AF4, and SEC compare in aggregate quantitation.
Feb 01, 2016
BioPharm International
The authors describe the impact of the knocking of the pgi gene of the wild type MG1655 strain on the growth kinetics of plasmid-free and plasmid-bearing cells.
Feb 01, 2016
BioPharm International
The authors review the status of expression of antibodies in microbial hosts and present the recent advances in the production of aglycosylated antibodies in bacteria.
Jan 28, 2016
By BioPharm International Editors
Novasep is building a new synthesis laboratory and adding capacity for kilogram-scale batches of synthetic molecules that are needed for biological testing and preclinical trials, at its Pennsylvania, US facility.
Jan 01, 2016
BioPharm International
The authors conclude that miniature bioreactors can adequately predict the cell culture kinetics in scaled-up reactors using equal mixing times.
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