Upstream Processing

Feb 09, 2006
BioPharm International
Over the last three decades, numerous protein expression systems have been developed with various quality requirements on large and small scales. Huge steps have been made in large-scale protein production in mammalian systems while the small-scale mammalian systems are expensive and inflexible. Thus, small-scale production is done in simpler expression systems, sometimes sacrificing the quality of the proteins. However, relief is on the way.
Feb 01, 2006
BioPharm International
Human infections with avian flu strain H5N1 are occurring in a number of southeast Asian countries that have experienced large outbreaks of avian influenza. How great a risk to the human population is posed by this virus, and what steps can be taken to minimize its impact? Preventive vaccines have great potential to avert the spread of avian flu and other infectious diseases. What are the factors affecting the creation of new vaccines, and how can they be optimized to promote public health?
Feb 01, 2006
BioPharm International
By BioPharm International Editors
Development guidelines for MAbs serve as a blueprint for their manufacture, safety, and efficacy testing.
Dec 01, 2005
BioPharm International
By BioPharm International Editors
The cell density achieved in a CELLine bioreactor is typically 1 to 2 orders of magnitude higher than in a conventional culture vessel
Nov 01, 2005
BioPharm International
By BioPharm International Editors
Use of a fermentor for cell culture study advances research in directions previously thought unimaginable.
Sep 01, 2005
BioPharm International
By BioPharm International Editors
Pharma industry equipment utilization hovers below 40 percent, which would be an unacceptable figure in most industries.
Aug 01, 2005
BioPharm International
By BioPharm International Editors
Subcutaneous administration is likely to be an important factor in generating an immunogenic response.
Aug 01, 2005
BioPharm International
By BioPharm International Editors
Various methods for transfecting molecules such as DNA, RNA, proteins, or drugs with high efficiency and low toxicity have been implemented and optimized for many different cell types. These include widely used techniques such as chemical transfection (lipid-based techniques), the use of viral vectors and electroporation.
Jul 01, 2005
BioPharm International
By BioPharm International Editors
Cell-line and process development expertise, along with disposable systems, assist in implementing strategies for fast expression enhancements.
Jun 01, 2005
BioPharm International
By BioPharm International Editors
Strategies for accurate speciation and case studies for the detection of cell line cross-contamination using a commercial kit.
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