Upstream Processing

Feb 01, 2006
BioPharm International
By BioPharm International Editors
Development guidelines for MAbs serve as a blueprint for their manufacture, safety, and efficacy testing.
Dec 01, 2005
BioPharm International
By BioPharm International Editors
The cell density achieved in a CELLine bioreactor is typically 1 to 2 orders of magnitude higher than in a conventional culture vessel
Nov 01, 2005
BioPharm International
By BioPharm International Editors
Use of a fermentor for cell culture study advances research in directions previously thought unimaginable.
Sep 01, 2005
BioPharm International
By BioPharm International Editors
Pharma industry equipment utilization hovers below 40 percent, which would be an unacceptable figure in most industries.
Aug 01, 2005
BioPharm International
By BioPharm International Editors
Subcutaneous administration is likely to be an important factor in generating an immunogenic response.
Aug 01, 2005
BioPharm International
By BioPharm International Editors
Various methods for transfecting molecules such as DNA, RNA, proteins, or drugs with high efficiency and low toxicity have been implemented and optimized for many different cell types. These include widely used techniques such as chemical transfection (lipid-based techniques), the use of viral vectors and electroporation.
Jul 01, 2005
BioPharm International
By BioPharm International Editors
Cell-line and process development expertise, along with disposable systems, assist in implementing strategies for fast expression enhancements.
Jun 01, 2005
BioPharm International
By BioPharm International Editors
Strategies for accurate speciation and case studies for the detection of cell line cross-contamination using a commercial kit.
May 01, 2005
BioPharm International
By BioPharm International Editors
Once a necessary "magic ingredient" of media for mammalian cell culture, serum is rapidly being eliminated from media for biotherapeutic processes.
May 01, 2005
BioPharm International
Saturated fractional factorial plans minimize the number of trials by one-half or better, which saves time and money.
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