Upstream Processing

Feb 01, 2016
BioPharm International
In this article, the author reviews some of the techniques that can yield valuable information on protein stability, focusing specifically on protein aggregation. Emphasis is placed on the enhanced information made available when technologies are used orthogonally, and the alignment of different approaches with specific stages of the biopharmaceutical development workflow.
Feb 01, 2016
BioPharm International
The authors describe the impact of the knocking of the pgi gene of the wild type MG1655 strain on the growth kinetics of plasmid-free and plasmid-bearing cells.
Feb 01, 2016
BioPharm International
The authors review the status of expression of antibodies in microbial hosts and present the recent advances in the production of aglycosylated antibodies in bacteria.
Jan 28, 2016
By BioPharm International Editors
Novasep is building a new synthesis laboratory and adding capacity for kilogram-scale batches of synthetic molecules that are needed for biological testing and preclinical trials, at its Pennsylvania, US facility.
Jan 01, 2016
BioPharm International
The authors conclude that miniature bioreactors can adequately predict the cell culture kinetics in scaled-up reactors using equal mixing times.
Jan 01, 2016
BioPharm International
Could perfusion microbioreactors bring more agility to biomanufacturing?
Dec 01, 2015
BioPharm International
Use of a subspace model is a viable method to characterize process space variables and optimize process performance.
Nov 30, 2015
A study backed by the Centre of Regenerative Medicine found that laminins are crucial cell components that could help aid the commercial production of stem cell therapies.
Nov 01, 2015
BioPharm International
The authors present a review of the techniques commonly used for glycosylation analysis.
Oct 29, 2015
By BioPharm International Editors
ProBioGen plans to develop and scale-up production of a biosimilar to the mAb cancer drug trastuzumab and will transfer the commercial manufacturing process to Indonesia’s government-owned Bio Farma.
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