Downstream Processing

BioPharm International: Mar 25, 2015
Design of Experiments (DoE), also called experimental design, is a statistical approach to process development that has gained wide acceptance in the biopharmaceutical industry. DoE is used to reduce development costs by speeding up the design process and to optimize the parameters of a particular step in the manufacturing process. The data presented here demonstrate the optimization of the CaPure-HA elution using a DoE approach.
BioPharm International: Mar 01, 2015
Recent technological advances in the way biologic therapeutics are purified may bring size-exclusion chromatography back into the modern purification process.
BioPharm International: Mar 01, 2015
Large-scale implementation of Protein A chromatography offers several challenges.
BioPharm International: Feb 01, 2015
They may not be glamorous, but buffers play an important role in biopharma manufacturing.
BioPharm International: Oct 31, 2014
Challenges remain for virus removal and validation.
Oct 21, 2014
By BioPharm International Editors
Pall ForteBio introduces a solution for quantifying residual host cell proteins in CHO cells.
BioPharm International: Sep 30, 2014
By BioPharm International Editors
A quality-by-design approach that defines potential viral contaminants of source materials can be used to achieve viral clearance.
BioPharm International: Aug 31, 2014
Careful selection of downstream processing conditions is a must.
BioPharm International: May 31, 2014
Suppliers see challenges to the adoption of single-use technologies for downstream processing as opportunities.
BioPharm International: May 31, 2014
Industry suppliers describe new technologies to facilitate downstream processing.