Downstream Processing

BioPharm International: Apr 30, 2015
Higher cell densities, greater demand for high-performance viral clearance, and desire for large-scale single-use technologies are driving development of filtration technologies.
BioPharm Bulletin: Apr 13, 2015
Use of ScreenExpert RoboColumns for high-throughput study of loading conditions on HyperCel™ STAR AX and MEP HyperCel Sorbents for mAb purification in flow-through mode.
Apr 05, 2015
By BioPharm International Editors
Pall’s acquisition of BioSMB from Tarpon Biosystems expands its downstream continuous processing offerings.
BioPharm International: Mar 31, 2015
Making the switch from batch to continuous manufacturing requires a thorough understanding of the process.
BioPharm International: Mar 25, 2015
Design of Experiments (DoE), also called experimental design, is a statistical approach to process development that has gained wide acceptance in the biopharmaceutical industry. DoE is used to reduce development costs by speeding up the design process and to optimize the parameters of a particular step in the manufacturing process. The data presented here demonstrate the optimization of the CaPure-HA elution using a DoE approach.
BioPharm International: Mar 01, 2015
Recent technological advances in the way biologic therapeutics are purified may bring size-exclusion chromatography back into the modern purification process.
BioPharm International: Mar 01, 2015
Large-scale implementation of Protein A chromatography offers several challenges.
BioPharm International: Feb 01, 2015
They may not be glamorous, but buffers play an important role in biopharma manufacturing.
BioPharm International: Oct 31, 2014
Challenges remain for virus removal and validation.
Oct 21, 2014
By BioPharm International Editors
Pall ForteBio introduces a solution for quantifying residual host cell proteins in CHO cells.