Downstream Processing

Jun 01, 2015
BioPharm International
This article reviews the definition of HCPs, risks posed by HCPs, regulatory concerns, commonly accepted ELISA methods for HCP measurement and their limitations, and orthogonal methods available for HCP characterization.
May 01, 2015
BioPharm International
Higher cell densities, greater demand for high-performance viral clearance, and desire for large-scale single-use technologies are driving development of filtration technologies.
Apr 14, 2015
By BioPharm International Editors
The single-use clarification system eliminates centrifuges; harvesting can be performed in one step; and process robustness and predictability are ensured.
Apr 06, 2015
By BioPharm International Editors
Pall’s acquisition of BioSMB from Tarpon Biosystems expands its downstream continuous processing offerings.
Apr 01, 2015
BioPharm International
Making the switch from batch to continuous manufacturing requires a thorough understanding of the process.
Apr 01, 2015
BioPharm International
Cation-exchange chromatography can be harnessed for challenging separations such as bispecific antibody, ADC, and mAb isoform purifications.
Mar 01, 2015
BioPharm International
By BioPharm International Editors
The all-synthetic clarifying product line contains both an anion-exchange nonwoven media and a fine-particle, bioburden reduction membrane.
Mar 01, 2015
BioPharm International
Recent technological advances in the way biologic therapeutics are purified may bring size-exclusion chromatography back into the modern purification process.
Mar 01, 2015
BioPharm International
Large-scale implementation of Protein A chromatography offers several challenges.
Feb 01, 2015
BioPharm International
They may not be glamorous, but buffers play an important role in biopharma manufacturing.
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