Downstream Processing

Jun 28, 2015
BioPharm International
By BioPharm International Editors
The new column features Natrix’s signature macroporous hydrogel.
Jun 14, 2015
BioPharm International eBooks
By BioPharm International Editors
Contract service providers share insights on biopharma market developments and the implications of biosimilar drug approvals.
May 31, 2015
BioPharm International
Removal of microorganisms is crucial when working with biologics. Sterile filtration offers a reliable, safe, and effective way to ensure product integrity.
May 31, 2015
BioPharm International
This article reviews the definition of HCPs, risks posed by HCPs, regulatory concerns, commonly accepted ELISA methods for HCP measurement and their limitations, and orthogonal methods available for HCP characterization.
May 13, 2015
As an important addition to the process development toolbox for platform process evaluation, Cadence™ Inline Concentrators (ILC), which utilize single-pass TFF technology, are crucial enablers of integrated, streamlined and continuous bioprocessing initiatives. ILC technology can remove constraints in existing facilities and increase the flexibility of manufacturing capabilities by increasing productivity and facilitating further use of disposables.
Apr 30, 2015
BioPharm International
Higher cell densities, greater demand for high-performance viral clearance, and desire for large-scale single-use technologies are driving development of filtration technologies.
Apr 13, 2015
BioPharm Bulletin
Use of ScreenExpert RoboColumns for high-throughput study of loading conditions on HyperCel™ STAR AX and MEP HyperCel Sorbents for mAb purification in flow-through mode.
Apr 05, 2015
By BioPharm International Editors
Pall’s acquisition of BioSMB from Tarpon Biosystems expands its downstream continuous processing offerings.
Mar 31, 2015
BioPharm International
Making the switch from batch to continuous manufacturing requires a thorough understanding of the process.
Mar 25, 2015
BioPharm International
Design of Experiments (DoE), also called experimental design, is a statistical approach to process development that has gained wide acceptance in the biopharmaceutical industry. DoE is used to reduce development costs by speeding up the design process and to optimize the parameters of a particular step in the manufacturing process. The data presented here demonstrate the optimization of the CaPure-HA elution using a DoE approach.