BioPharm International Supplements, June 2006 - BioPharm International

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BioPharm International Supplements, June 2006
Articles
Technical and Economical Evaluation of Downstream
By Gunter Jagschies, PhD , Anna Gronberg , Tomas Bjorkman , Karol M. Lacki , Hans J. Johansson
Downstream process design can increase facility output through improved overall process yield or higher batch capacity in mass and volume.
Downstream Process Optimization Opportunities Using
By George Barringer
The purpose of the PAT initiative is to move analytical laboratory functions close to the manufacturing process to improve manufacturing efficiency and product quality.
Development of a Novel Platform TFF System for Insect
By Richard Chubet , James Kacmar , Hank Kopf
The overall average flux rate for the concentration and diafiltration step was 41 L m–2 h–1.
The Renaissance of Protein Purification
The polishing process—unlike capturing—is beginning to benefit from technological advances.
Chromatography Process Development Using 96-Well Microplate Formats
By Henry Charlton , Ben Galarza , Kelly Leriche , Rob Jones
Using packed columns in process development activities limits the scope for appraising a large and diverse range of media.
Filtration Designs Remove Processing Bottlenecks
By Monica Cardona , Oliver G. Inseal
Biotech companies are running into production bottlenecks because standard purification and separation technologies lack the capability to remove the elevated levels of biomass from high titer solutions. Recent developments in filter technology offer the biotech industry a cost-effective solution to processing challenges by reducing bottlenecks, thereby accelerating the time-to-market of new drugs.

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