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Technical and Economical Evaluation of Downstream
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| By
Gunter Jagschies, PhD
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Anna Gronberg
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Tomas Bjorkman
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Karol M. Lacki
,
Hans J. Johansson
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Downstream process design can increase facility output through improved overall process yield or higher batch capacity in mass and volume.
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Filtration Designs Remove Processing Bottlenecks
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Monica Cardona
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Oliver G. Inseal
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Biotech companies are running into production bottlenecks because standard purification and separation technologies lack the capability to remove the elevated levels of biomass from high titer solutions. Recent developments in filter technology offer the biotech industry a cost-effective solution to processing challenges by reducing bottlenecks, thereby accelerating the time-to-market of new drugs.
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Downstream Process Optimization Opportunities Using
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| By
George Barringer
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The purpose of the PAT initiative is to move analytical laboratory functions close to the manufacturing process to improve manufacturing efficiency and product quality.
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Chromatography Process Development Using 96-Well Microplate Formats
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| By
Henry Charlton
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Ben Galarza
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Kelly Leriche
,
Rob Jones
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Using packed columns in process development activities limits the scope for appraising a large and diverse range of media.
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Development of a Novel Platform TFF System for Insect
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Richard Chubet
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James Kacmar
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Hank Kopf
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The overall average flux rate for the concentration and diafiltration step was 41 L m–2 h–1.
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The Renaissance of Protein Purification
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The polishing process—unlike capturing—is beginning to benefit from technological advances.
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