BioPharm International, August 2004 - BioPharm International

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BioPharm International, August 2004
Plant-Made Pharmaceuticals
Green Plants as Biofactories for Drugs
By Juliet A. Zavon , James E. Flinn
Green plants and production systems that are most removed from conventional commercial food and feed crops are most likely to succeed
Production and Processing
Producing Affordable, High-Purity Water
By Robert C. Livingston , Hank Moes
A water distribution plan is at the heart of an overall energy and water conservation program.
Filtration
Optimization, scale-up, and validation issues in Filtration of Biopharmaceuticals, Part 1
By Anurag S. Rathore, PhD , Alice Wang , Manoj Menon , Jerold Martin , Jennifer Campbell , Elizabeth Goodrich , Frank Riske
Filtration is one of the most commonly used unit operations in biopharmaceutical manufacturing. Available formats include direct or normal flow filtration (NFF) and cross or tangential flow filtration (TFF). These methods are used for sterilization and virus filtration, depth filtration or ultrafiltration, and diafiltration applications. Some common objectives include:
Separation and Purification
Affinity Chromotography - from Textile Dyes to Synthetic Ligands by Design, Part 2
By John Curling
Synthetic ligand adsorbents can eliminate the potential hazards of animal- and microorganism-sourced ligands, minimizing running, cleaning, and validation costs.
Columns and Departments
Regulatory Beat: FDA Proposes New Systems and Procedures for E-filing Labeling and Other Data
By Jill Wechsler
One main component of an e-prescribing system is access to accurate, up-to-date information on prescription drugs and biologics based on FDA-approved labeling.
StreetTalk: PMPs: Easy as 1-2-3?
By Brian O'Connell
Like any other financial venture, investing in PMPs requires both the patience of a saint and the ability to absorb some bad news and still hang in there.
Applications: A Total Water Purification System
By Jeffrey Denoncourt
Although sounding like a singular term, a water purification system actually consists of several key components.
Outsourcing Report: Contract Players
By Jim Miller
Technology innovations aimed at increasing yields and shortening development times can be very cost-effective, promising to reduce the need for large capital investments while getting the client into the clinic much faster.
Final Word: Plant-Made Pharmaceuticals
By Sabrina Wagner
There is no current capacity crunch due to increased investments in new facilities.
Editorial—Welcome to Our PMP Series
By Carol L. Fisher
What were you doing on the evening of July 20, 1969? If you are at least a baby boomer, you were probably watching Neil Armstrong take "one small step for man, one giant leap for mankind." Sputnik aside, the birth of that monumental achievement probably began with the same question that sparked so many other great feats: "What if?" Where would civilization be if someone periodically hadn't had the imagination and the courage to ask that question, whether their field of expertise was aeronautical engineering, architecture, or biotechnology?

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