BioPharm International, October 2013 - BioPharm International

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BioPharm International, October 2013
Cover Story
Angiopoietins: Novel Targets for Anti-angiogenesis Therapy
By Rathin C. Das, PhD , K. John Morrow, Jr., PhD
The authors review the angiopoietin pathway as an alternative for safer and more efficacious anti-angiogenic therapeutics.
Special Section
Increasing Capacity Utilization in Protein A Chromatography
By Thomas Mueller-Spaeth, PhD , Monica Angarita , Daniel Baur , Roel Lievrouw , Geert Lissens , Guido Stroehlein, PhD , Michael Bavand , Massimo Morbidelli, PhD
A twin-column periodic countercurrent capture process that combines an efficient sequential, countercurrent loading process with a minimal twin-column hardware configuration is described.
Peer-Reviewed Research
Definition of a Security Value Determined by Limulus Amebocyte Lysate Assay Targeting the Recombinant Human Epidermal Growth Factor
By Julio César Sánchez García , Neyda Hernández Caso , Roxana Hernández González , Alexis Musacchio Lasa , Alexey Llopiz Arzuaga , Hector Santana Millan , Vivian Pujol García , Virgilio Bourg
The correlation between limulus amebocyte lysate (LAL) assay and rabbit pyrogen test (RPT) targeting recombinant human epidermal growth factor (rhEGF) as active molecule was assessed.
Regulatory Beat
FDA Seeks Metrics to Define Drug Quality
By Jill Wechsler
Manufacturing standards are considered key to preventing drug recalls and shortages.
Analytical Best Practices
Performing a Protein Purity Analysis Comparability Study
A well-designed comparability study can demonstrate the performance and advantages that can be gained when adopting a new protocol.
Perspectives on Outsourcing
The Expense of Vision in Outsourcing
By Jim Miller
Practicality of implementation should be a part of vision in the bio/pharmaceutical industry.
Global Report
Report from Myanmar
By Jane Wan
Foreign companies zero in on Myanmar with the hope of securing a foothold in its pharmaceutical market.
Navigating Emerging Markets: Middle East and North Africa
By Jill E. Sackman, PhD
The pharmaceutical industry grows despite conflict in the Middle East.
Burrill on Biotech
Robust IPO Market for Life Sciences Sparks Change Among Investors
By G. Steven Burrill
Early-stage companies are now embraced by buyers of new issues.
Compliance Notes
Operational Excellence: More Than Just Process Improvement
By Ian Uydess , Robert E. Spector
By embracing efficiency and quality, biopharmaceutical organizations can work better and achieve better work.
Guest Editorial
Changing the Dynamic of CROs
By Anthony DeStefano
Through its educational and networking opportunities, the American Association of Pharmaceutical Scientists plays an important role in partnering throughout the drug- development and commercialization process.

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