BioPharm International Supplements, June 2010 - BioPharm International

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BioPharm International Supplements, June 2010
Articles
Balancing Media Development with Patient Safety
By Michelle Lea, PhD
The quest for increased productivity and better process control combined with patient safety has encouraged biopharmaceutical companies to use chemically defined media for cell culture.
Partial Replacement of Chemically Defined Media with Plant-Derived Protein Hydrolysates
By James Babcock, PhD , Christopher Wilcox, PhD , Hans Huttinga
Plant-derived hydrolysates can be used as valuable and practical tools to improve cell culture performance.
Using Information Technology to Enhance Upstream Productivity
By Karl Rix, PhD , Martin Grolms
Two case studies show how advanced information technologies make process development more efficient.
Best Practices for Microbial Fermenter Equipment Characterization
By Kirsten Hayda , Maria Wik , Valerie Pferdeort
Wet testing of microbial fermenters allows for a greater understanding of the equipment's capabilities.
Developing an Automatically Controlled Feeding Process in an E. coli Fermentation Process for Recombinant Protein Production
By Julieta Aulicino , Matilde Hermida , Raśl Medina , Lorena Sabarots , Luis Ducrey , Eduardo Orti , Florencia Rogers
An exponential feeding strategy coupled with automation doubled protein yields while reducing fermentation time by 25%.

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