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Balancing Media Development with Patient Safety
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| By
Michelle Lea, PhD
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The quest for increased productivity and better process control combined with patient safety has encouraged biopharmaceutical companies to use chemically defined media for cell culture.
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Partial Replacement of Chemically Defined Media with Plant-Derived Protein Hydrolysates
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| By
James Babcock, PhD
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Christopher Wilcox, PhD
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Hans Huttinga
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Plant-derived hydrolysates can be used as valuable and practical tools to improve cell culture performance.
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Using Information Technology to Enhance Upstream Productivity
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| By
Karl Rix, PhD
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Martin Grolms
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Two case studies show how advanced information technologies make process development more efficient.
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Best Practices for Microbial Fermenter Equipment Characterization
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| By
Kirsten Hayda
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Maria Wik
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Valerie Pferdeort
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Wet testing of microbial fermenters allows for a greater understanding of the equipment's capabilities.
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Developing an Automatically Controlled Feeding Process in an E. coli Fermentation Process for Recombinant Protein Production
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| By
Julieta Aulicino
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Matilde Hermida
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Raśl Medina
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Lorena Sabarots
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Luis Ducrey
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Eduardo Orti
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Florencia Rogers
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An exponential feeding strategy coupled with automation doubled protein yields while reducing fermentation time by 25%.
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